If see difficulties coming..
You’ll have big problems if you set all your money on one horse. You never know.

So, I would suggest to make an API for JS Frameworks, which would again raise the timeline to 096, but sure you will have the greatest flexibility to switch between libs withous problems, and everybody would be happy.
You can optimize the API for MooTools in example, but give the opportunity to code api extensions, so called plugins for ie. jQuery.
It would save the time to recode your manager "scripts", because of version updates and incompatibilities.
This are my suggestions aslong as you don’t sleep in one bed with a framwork and know it’s next step
This would be the greatest and most amazing step towards JAVASCRIPT and CMS CONFLUENCE.
Keep is up 2 date daddy