I used Blue Print just before xmas for a small gallery website and found it speeded up my CSS process.
Being the first CSS framework I’ve used I was initially quite sceptical however it helped, I would recommend it however I will be looking at alternatives. 960 and BlueTip both look interesting, I’m slightly concerned that BluePrint is becoming bloated. The resets are certainly a big bonus, I just hate spending time tweaking styling for cross browser compatibility and would sooner spend time on more interesting code like jQuery.
I’m currently in the process of building my own ’Design Agency’ site and will not be using a grid, why?, I will have one page with all content presented via jQuery so in such cases light optimized custom code seems logical. In short if you need a grid use a Framework if not then its only additional overhead.
Great topic, many interesting links
ps, site designed was www.samhenwood.co.uk [i](I’ll give her a plug lol)[/i]