I want to confirm this bug. MODx 2.3.5, logged in as admin/sudo. It doesn't seem to register any input on the Media Source editing screen unless you save and then clear the cache. Could this simply be because Media Sources should send a "Clear Cache on Save" event, but they aren't for some reason?
How about maybe an incompatibility with a plugin, like pThumb for instance (which is installed on this particular site)?