I use the
Logitech K800 wireless, illuminated KB. It has an old-fashioned layout that I really like with a full numeric keypad. I've swapped the Ctrl and left-shift keys so I can type Ctrl-c, Ctrl-v, Ctrtl-x, and Ctrl-b without moving my left hand. It's also really quiet, has great action, and has a few handy extra keys (calculator, volume controls, etc.). Best of all, it's lighted, so I can work in complete darkness if I feel like it. It only lights when your hand is near it. The battery usually lasts for a week or two before it needs recharging.
For a mouse, I use the
Logitech M570 Wireless Trackball. I have the sensitivity maxed out so I can move the mouse from one side of the screen to the other with a small movement of my thumb. It takes a little getting used to, but I can work all day and all night without any discomfort at all -- ever -- because I never have to use my wrist muscles. I have a smooth
Fellowes Gel Pad in front of it.
Both the KB and mouse have a three-year warranty and use the same universal USB mini-dongle (which I've collected a bunch of), so I can use them both on multiple computers with no setup. I've used the warranty several times, and as long as you have the original receipt (which Amazon keeps for you), you don't have to send them back and you get a new one in a few days.
The only down side is that they seldom last three years if you use them constantly, but with the warranty, I usually get about 5 years out of them. I keep a spare on hand for each one so I don't have any down time if they go bad.