I wish I could help. The only things I can think of to try are disabling *all* plugins, and if that doesn't work, clear the cache, flush all sessions, log out, delete all files in core/cache, clear browser cache and cookies again, re-download 2.2.4, and be sure *not* to use FTP to tranfer the files to the site, then run Setup.
You could also double check all the paths in core/config/config.inc.php and all the config.core.php files.
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PLEASE, PLEASE specify the version of MODX you are using.
MODX info for everyone:
http://bobsguides.com/modx.html