Where are the extra slashes coming from? Do you by chance have magic_quotes_gpc enabled? If you don't have links like that on the site, how would a user ever end up at mydomain.com/////?
That said, I think this rewrite rule might do it:
RewriteRule ^mydomain.com/[/]+ http://mydomain.com/ [R=301,NC]
Though it will slow down the site slightly.
As always, back up your .htaccess file before making any changes.
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