We just ran into this same problem as well. A new client has come to us and they had a MODX Revo install (version 2.2.1) running on a server and it stopped working altogether. We're not sure if it's a hosted related problem or MODX problems that kept the site from running. They wanted to move to a new server anyways, so we moved all the files over to the new server: Bluehost.com which is MODX friendly (and by MODX friendly I mean they have Fantastico enabled to install MODX on their server).
So we went ahead and upgraded the site to run on 2.2.8 and we were able to get things running again. Now we're running into this problem. When attempting to save a document, we're getting an "Access Denied" error. So we went over to the Security >> Manage Users and instead of seeing the users, we see this:
http://screencast.com/t/PAr8ukPJ4XIE
It's the same error as above: "action_err_ns"
We've attempted to perform the steps above with updating the .htaccess file but it didn't help. I went ahead and did a clean install of MODX on the server in a dev directory and everything is working fine on the dev modx install (just a base install).
Not sure what to do now. The site will load, but we can't make any updates in the MODX manager.
Here's what 1 thing I have really observed about the manager: every action made that has an ajax request, the MODX manager returns this error. Also, we were seeing this error before we did the upgrade.