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Yes. For manager (and web, or visitor) user management, see the Security menu item. Manager users are controlled by role, which specifies what they can do, and user group membership, which when combined with document groups (for the documents) determines what documents they can access.
And again, yes. The manager interface is controlled by the manager/media/style/MODxCarbon files; as well as some in assets/templates/manager. You can duplicate the MODxCarbon directory, then edit the css and other files as you please.
You can control the content of the Manger interface using the ManagerManager plugin.