In your case I would use 2 templates
First create the 2 templates:
Home will have
<!-- start content area -->
<div id="innerwrap">
<div id="content">[*#content*]</div>
<div id="right">[*rightContent*]</div>
</div>
<!-- end content area -->
The second template will be
<!-- start content area -->
<div id="innerwrap">
<div id="content"> <p>[*#content*]</p> </div>
</div>
<!-- end content area -->
For the home template create a TV called "rightContent":
Variable Name: rightContent
Caption: Right Content
Input Type: Rich Text
Save
Make sure the Home page has assigned the home template. Another text box called Right Content should be available.
Create a second page and assign the second template.
If you want that all the pages be created using the second template go to Tools, Configuration and enter the second template id for "Site Start".
If you do not have a menu you should have a look at wayfinder:
http://www.muddydogpaws.com/development/wayfinder/examples.html