is it maybe a static chunk?
Issues with mod security on your server can sometimes cause issues like this I've found.
<p>Hello</p>
Try emptying the chunk (saving the content somewhere else) and just putting something simple like this in the content field:
<p>Hello</p>
If that saves correctly it's almost certainly mod_security objecting to something in the content.
You can try bringing back parts of the content one at a time to zero in on the content that's triggering mod_security.
When a particular chunk, resource, or template won't save but others will, at least nine times out of ten the problem is mod_security.