Mod Security question

I frequently run into problems with saving documents in the manager because of Mod Security and the steps in the wiki never seem to help, we recommend the same VPS account (with liquidweb) so I wanted to know if anyone can help keeping as much as enabled as possible while not conflicting with the manager.

In the past I solve the problem by clearing out the Mod Security, if anyone can suggest what lines to comment out in the attached file that would be great, I have no clue where to even start and things I have tried never seem to work.

Thanks!
Dustin Walker